Female Infertility

Female Infertility

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There are many causes of female infertility, but stem cells may offer a potential treatment for some forms of the condition.

Premature ovarian failure (POF) is one type of infertility that could be treated with stem cells. In POF, the ovaries stop functioning before a woman reaches the age of 40. This can result in many problems, including hot flashes, night sweats, and vaginal dryness. Stem cell therapy may help by regenerating the ovaries and restoring their function.

Endometrial disorders are another type of infertility that could potentially be treated with stem cells. Endometriosis is when the endometrium, the lining of the uterus, grows outside the uterus, often causing pain, bleeding, and infertility. Stem cell therapy may help regenerate the endometrium and restore its normal function.

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There is still much research to be done in this area, but stem cells show promise as a potential treatment for female infertility, so if you are suffering,  talk to your doctor about whether stem cell therapy could be right for you.

In some uterine diseases, the intrauterine application of stem cells improves the thickness and quality of the endometrium and increases implantation and the probability of pregnancy (4,5). According to the results of several reviews and clinical trials, stem cells have been beneficial in restoring the fertility of women with infertility due to various causes (4-10).


1. Zhao YX, Chen SR, Su PP, Huang FH, Shi YC, Shi QY, et al. Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases. Stem Cells Int. 2019:9071720. doi: 10.1155/2019/9071720.
2. Mohamed SA, Shalaby S, Brakta S, Elam L, Elsharoud A, Al-Hendy A. Umbilical Cord Blood Mesenchymal Stem Cells as an Infertility Treatment for Chemotherapy Induced Premature Ovarian Insufficiency. Biomedicines. 2019;7(1). pii: E7. doi: 10.3390/biomedicines7010007.
3. Vermeulen M, Giudice MG, Del Vento F, Wyns C. Role of stem cells in fertility preservation: current insights. Stem Cells Cloning. 2019;12:27-48. doi: 10.2147/SCCAA.S178490.
4. Jahanbani Y, Davaran S, Ghahremani-Nasab M, Aghebati-Maleki L, Yousefi M. Scaffold-based tissue engineering approaches in treating infertility. Life Sci. 2020;240:117066. doi: 10.1016/j.lfs.2019.117066.
5. Rungsiwiwut R, Virutamasen P, Pruksananonda K. Mesenchymal stem cells for restoring endometrial function: An infertility perspective. Reprod Med Biol. 2020;20(1):13-19. doi: 10.1002/rmb2.12339.
6. Ding L, Yan G, Wang B, Xu L, Gu Y, Ru T, et al. Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with a long history of infertility. Sci China Life Sci. 2018;61(12):1554-1565. doi: 10.1007/s11427-017-9272-2.
7. Zafardoust S, Kazemnejad S, Darzi M, Fathi-Kazerooni M, Rastegari H, Mohammadzadeh A. Improvement of Pregnancy Rate and Live Birth Rate in Poor Ovarian Responders by Intraovarian Administration of Autologous Menstrual Blood-Derived- Mesenchymal Stromal Cells: Phase I/II Clinical Trial. Stem Cell Rev Rep. 2020. doi: 10.1007/s12015-020-09969-6.
8. Esfandyari S, Chugh RM, Park HS, Hobeika E, Ulin M, Al-Hendy A. Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility. Cells. 2020;9(10):E2253. doi: 10.3390/cells9102253.
9. Pourakbari R, Ahmadi H, Yousefi M, Aghebati-Maleki L. Cell therapy in female infertility-related diseases: Emphasis on recurrent miscarriage and repeated implantation failure. Life Sci. 2020;258:118181. doi: 10.1016/j.lfs.2020.118181.
10. Rosario R, Anderson RA. Novel approaches to fertility restoration in women with premature ovarian insufficiency. Climacteric. 2021:1-13. doi: 10.1080/13697137.2020.1856806.

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